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Elucidation of Atomic-level Mechanisms in Which a Pair of Hydrogen-ion Permeable Proteins Function (Press Release)

Release Date
09 May, 2012
  • BL44XU (Macromolecular Assemblies)
—We now know the mechanism whereby we raise our body temperature to protect our bodies from invading germs—

Osaka University

A joint research team led by Assistant Prof. Yuichiro Fujiwara, Prof. Yasushi Okamura (Integrative Physiology, Graduate School of Medicine & Frontier Bioscience), and Prof. Atsushi Nakagawa (Institute for Protein Research) revealed the atomic-level mechanism inherent in the human body that expels invading germs: two hydrogen-ion permeable proteins coalesce (formation of a dimer) to control in-vivo pH in tune with body temperature. The results, which are also an important discovery from the viewpoint of biological defense response and are typically infection-associated fever, were published in Nature Communications, a British online journal, on May 5, 16:00 hrs GMT.

Publication:
Fujiwara Y., et. al.
"The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H+ channel Hv1"
Nature Communications 3, 816 (2012) published online 08 May 2012

<<Figures>>

fig.1.

For more information, please contact:
　　Dr. Yuichiro Fujiwara (Osaka University)
　　　　　E-mail :

　　Prof. Yasushi Okamura (Osaka University)
　　　　　E-mail :

　　Prof. Atsushi Nakagawa (Institute for Protein Research, Osaka University)
　　　　　E-mail :

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