Development of microbeam radiation therapy system
Inquiry number
SOL-0000001733
Beamline
BL28B2 (White Beam X-ray Diffraction)
Scientific keywords
| A. Sample category | biology, medicine |
|---|---|
| B. Sample category (detail) | biology (in vivo) |
| C. Technique | absorption and its secondary process |
| D. Technique (detail) | |
| E. Particular condition | microbeam (> 10 µm) |
| F. Photon energy | X-ray (> 40 keV) |
| G. Target information |
Industrial keywords
| level 1---Application area | others |
|---|---|
| level 2---Target | |
| level 3---Target (detail) | organism |
| level 4---Obtainable information | |
| level 5---Technique |
Classification
A80.90 others
Body text
Microbeam radiation therapy (MRT) is under way for understanding of the biological effects of MRT on the tumorous microvasculature in a rat model of cancer. Rat brains implanted with carcinoma will be irradiated for the study of microvascular biological response in tumor angiogenic vessels following MRT.
Source of the figure
No figure
Technique
Microplanar X-ray beams are produced from a white synchrotron radiation beam using a multi-slit collimator and metal filters for hardening the X-ray beam. The multi-slit collimator provides array of microbeams (beam width of 25 µm and distance between slits 200 µm) for MRT. An ion chamber can estimate the dose rate in Gy/sec during the irradiations.
Source of the figure
No figure
Required time for experimental setup
3 hour(s)
Instruments
| Instrument | Purpose | Performance |
|---|---|---|
| Irradiation system | Microbeam radiation therapy | A median energy of approximately 120 keV |
References
Related experimental techniques
Questionnaire
This solution is application of a new instrument installed in the past two years.
Ease of measurement
Middle
Ease of analysis
Middle
How many shifts were needed for taking whole data in the figure?
Two-three shifts