In vivo measurement of cerebral blood vessel response in rats
問い合わせ番号
SOL-0000001732
ビームライン
BL28B2（白色Ｘ線回折）
学術利用キーワード
| A. 試料 | 生物・医学 |
|---|---|
| B. 試料詳細 | 生体（in vivo） |
| C. 手法 | 吸収、及びその二次過程 |
| D. 手法の詳細 | |
| E. 付加的測定条件 | 二次元画像計測, 時分割（ミリ秒） |
| F. エネルギー領域 | Ｘ線（4～40 keV) |
| G. 目的・欲しい情報 |
産業利用キーワード
| 階層1 | 製薬 |
|---|---|
| 階層2 | ドラッグデザイン |
| 階層3 | 薬物, 生体 |
| 階層4 | 形態 |
| 階層5 | イメージング |
分類
A80.90 その他
利用事例本文
This study was focused on the radiographical evaluation of changes in small cerebral arteries that have never been previously observed. Small arteries arising directly from major trunk vessels are known as perforators that supply arterial blood to the basal nucleus. These perforators are more important than pial arteries when considering the affects of systemic disease on cerebral vessels. The distension of trunk arteries and their small branches was measured under hypercapnia and hypotension using microangiography. With this technique, various sizes of vessels were observed. In addition, pharmacological manipulations were applied to the local brain environment.
画像ファイルの出典
図なし
測定手法
The imaging system was composed of an X-ray direct-conversion-type detector incorporating an X-ray SATICON pickup tube and a high-speed X-ray shutter. Microangiographic images were obtained at a maximum rate of 30 images/s and stored in a frame memory system with a 1024×1024-pixel, 10-bit. Sequential images were obtained with an input field of view of 9.5×9.5 mm with resolution to 10 µm. The imaging field can include not only intracranial cerebral vessels but also the pterygopalatine artery which is running through the extracranial region.
画像ファイルの出典
BL評価プレゼン資料
測定準備に必要なおおよその時間
3 時間
測定装置
| 装置名 | 目的 | 性能 |
|---|---|---|
| Angiograpy system | Microangiography | 6-10 micron resolution |
参考文献
関連する手法
no
アンケート
SPring-8だからできた測定。他の施設では不可能もしくは難しい
測定の難易度
中程度
データ解析の難易度
中程度
図に示した全てのデータを取るのにかかったシフト数
2～3シフト