走査蛍光Ｘ線顕微法
Inquiry number
SOL-0000001538
Beamline
BL29XU (RIKEN Coherent X-ray Optics)
Scientific keywords
| A. Sample category | inorganic material, organic material, biology, medicine |
|---|---|
| B. Sample category (detail) | metal, alloy, semiconductor, insulator, ceramics, organism, cell, biological material |
| C. Technique | fluorescent X-rays |
| D. Technique (detail) | trace-element |
| E. Particular condition | microbeam (1-10 µm), microbeam (sub-µm), 2D imaging |
| F. Photon energy | X-ray (4-40 keV) |
| G. Target information | structure analysis, function and structure |
Industrial keywords
| level 1---Application area | environment, Pharmaceuticals |
|---|---|
| level 2---Target | drug design, Environmental material |
| level 3---Target (detail) | organism |
| level 4---Obtainable information | element distribution |
| level 5---Technique | imaging |
Classification
A80.20 metal ・material, A80.30 inorganic material, A80.32 organic material, A80.50 Pharmaceuticals, A80.90 others
Body text
走査蛍光Ｘ線顕微法は元素分布を調べることのできる有効な手法です。超精密Ｘ線全反射ミラーで構成されたKirkpatrick-Baez型Ｘ線集光系を用いることにより、数十ナノメートルの空間分解能を持つ元素マップが可能となります。
図に示すのは、CDDP感受性および耐性癌細胞について測定した元素マップです。15 keV のＸ線を、試料位置で1.5 m (H) 0.75 m (W)に集光しました。 この結果から、癌の新規治療法が提案されました。
図 走査蛍光Ｘ線顕微法による癌細胞の元素マップ
[ M. Shimura, A. Saito, S. Matsuyama, T. Sakuma, Y. Terui, K. Ueno, H. Yumoto, K. Yamamura, H. Mimura, Y. Sano, M. Yabashi, K. Tamasaku, K. Nishio, Y. Nishino, K. Endo, K. Hatake, Y. Mori and Y. Ishizuka, Cancer Research 65, 4998-5002 (2005), Fig. 1,
©2005 American Society of Cancer Research ]
Source of the figure
Original paper/Journal article
Journal title
M. Shimura, A. Saito, S. Matsuyama, T. Sakuma, Y. Terui, K. Ueno, H. Yumoto, K. Yamauchi, K. Yamamura, H. Mimura, Y. Sano, M. Yabashi, K. Tamasaku, K. Nishio, Y. Nishino, K. Endo, K. Hatake, Y. Mori, Y. Ishizaka, and T. Ishikawa, Cancer Res. 65, 4998-5002 (2005)
Figure No.
１
Technique
二枚の集光ミラーをKirkpatrick-Baez配置で用いX線ビームを二次元集光します。蛍光Ｘ線分光はシリコンドリフト検出器を用いて行います。
Source of the figure
No figure
Required time for experimental setup
hour(s)
Instruments
| Instrument | Purpose | Performance |
|---|---|---|
| Kirkpatrick-Baez型Ｘ線集光装置 | ||
| シリコンドリフト検出器 |
References
| Document name |
|---|
| M. Shimura, A. Saito, S. Matsuyama, T. Sakuma, Y. Terui, K. Ueno, H. Yumoto, K. Yamauchi, K. Yamamura, H. Mimura, Y. Sano, M. Yabashi, K. Tamasaku, K. Nishio, Y. Nishino, K. Endo, K. Hatake, Y. Mori, Y. Ishizaka, and T. Ishikawa, Cancer Res. 65, 4998-5002 (2005) |
Related experimental techniques
Questionnaire
With user's own instruments.
Ease of measurement
With a great skill
Ease of analysis
With a great skill
How many shifts were needed for taking whole data in the figure?
Four-nine shifts