SPring-8, the large synchrotron radiation facility

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Public Beamline& Contract Beamline User and those who apply for user proposal offered by the Users Office

Handling of chemical substances

Many of chemicals used in experiments have hazardous properties. Handle them safely, giving sufficient consideration to health issues, disaster preparedness, theft/loss and environmental pollution. Principal investigators(Project leader) are responsible for correctly managing chemicals used in their research projects and providing their workers with training for proper handling. In order to limit damage caused by fire, bring burnable items into the laboratories only in the amount you need. As the experimental hall was designed so that controlling the flow of temperature and humidity is given a high priority, the facility is not optimal for conducting chemical experiments. When experiments using organic solvents or specified chemical substances are conducted at most of the 50 beam lines, even if the amount used per beam line is small, the total amount is so large that the vaporized or scattered chemicals may result in a deteriorated working environment. Please perform such experiments in a location where a draft chamber is installed.

(1)Chemicals that are allowed to be used
SPring-8/SACLA does not have any specific regulations regarding this matter. However, please consult the JASRI Users Office before using substances that require approval by the government authorities. It takes time to submit notifications and to obtain approval. Substances that require consultation prior to use: narcotics, stimulants, raw materials for stimulants, psychotropics, and specified chemical substance.

→Information for those who are bringing medicines for personal use into Japan link

→Examples of Dangerous Goods by Air Transportation :goods list link ,IATA

→Import Procedures:Japan Customs

→cf.)Japanese Law seach;Japanese law Translation

(2)Locations allowed to be used for experiments

The experimental hall is equipped with draft chambers that can be used for experiments involving risk of scattering dust, specified chemical substances and organic solvents. When you are going to conduct such experiments, contact the staff in charge.
● Chemical Sample Preparation Room: refer to here for details on application for use and the likeLink

● BL02 and BL13: consult personnel in charge.

(3)Storage cabinets
Deleterious/poisonous substances and the like brought into the facility must be stored in the cabinets properly. In the experimental hall, storage cabinets are installed and users may borrow the keys to the cabinets when needed. Please contact the person in charge of beam lines to borrow the key to a cabinet used for controlling such substances.

Procedures to be followed in advance by principal investigators

(1) Entry of safety report in application form for research project
Project leaders are required to report the properties, hazards and safety measures of chemicals that will be used in their proposal by referring to SDS (safety data sheet), as follows.


(2) Knowing legal category and safety information of chemical

(2.1) Chemical categories based on Japanese legal regulations
*link to out side
 Poisonous Substances
 Deleterious Substances
 Organic Solvents
 Specified Chemical Substances
 Flammable/Explosive Substances

(2.2) Finding information of chemical 
*link to out side
 Searching for legal categories and safety information by chemical names or CAS numbers

(3) Risk assessment

Any organization handling chemicals is obliged to perform the following risk assessment of specified chemicals due to the Japanese new regulation effective June 1, 2016.
- Investigate chemical hazards to humans depending on handling conditions.
- Consider the measures to control exposure to chemicals to reduce the hazard risk.
The Chemicals used in the proposed experiments at SPring-8/SACLA also must be assessed by the persons/organizations in charge of the experiments. JASRI requires project leaders to report the results of the risk assessment, and the reports will be referred in the safety reviews of proposed experiments.
If your organization has not introduced the risk assessment of chemicals, we recommend you to perform Control Banding, a practical simple method to evaluate hazard risk and to control exposure to chemicals.
For example, "COSSH e-tool" is one of well known easy online tools.
When the risk level result means that you need some measures to reduce the risk for your health, please explain your measures in the field of "Prevention of Hazards".
Please refer the following UI page for detail.
About risk assessment of chemicals used in proposed experiments


Procedures to be taken from the beginning to the end of experiments

(1)Handling of chemical substances

Signs required to be posted
1) Post the following signs on storage containers for narcotics (left) and psychotropics (right).
narcotics (left) and psychotropics (right)
2)Non-medical poisonous substances (including specified toxic substances), non-medical deleterious substances
a)Store non-medical poisonous substances in storage cabinets with the following sign attached.
non-medical poisonous substances
b)Store non-medical deleterious substances in storage cabinets with the following sign attached.
non-medical deleterious substances
c)Post one of the following signs on storage cabinets of poisonous/deleterious substances.
non-medical poisonous substances(white background and the word written in red) non-medical deleterious substances(red background and the word written in white)

3) Medication
Store poisons and powerful drugs separately from other medication in locked storage cabinets. The following signs must be posted on storage cabinets of poisons (left) and powerful drugs (right).
poisons (left) and powerful drugs (right)
Rules for storage

Chemicals are regulated by related laws and regulations according to their properties. They are also regulated by rules specified by SPring-8/SACLA. Please observe these rules while taking the following measures.

1) Narcotics, stimulants, raw materials for stimulants, psychotropics.

Store separately from other reagents in storage cabinets that are always locked, as described in the application submitted to the government authorities.

2) Non-medical poisonous substances (including specified toxic substances), non-medical deleterious substances

a)Always lock storage cabinets of non-medical poisonous substances. Keep records for the amount used and stocked. Store specified toxic substances in designated storage cabinets as described in the application submitted to the government authorities.

b)Always lock storage cabinets of non-medical deleterious substances. Keep records for the amount used and stocked.

3) Medicine

Store poisons and powerful drugs separately from other medicines in locked storage cabinets.

4) Dangerous substances

Carefully handle flammable substances such as volatile organic solvents and explosive substances that can cause a fire easily and spread a fire leading to great damage. Do not place glass containers such as gallon bottles directly on the floor. When such containers break (when kicked or hit with a chair, for example), the contents will spread onto the floor, resulting in a higher risk of accidents. Please take safety measures, such as placing a tray and the like under the containers.

5) Other reagents

Storage and control of other reagents must conform to related laws and regulations. Please control and store them in a manner appropriate to the properties of each reagent.


Handling of chemicals

Many of chemicals used for experiments have hazardous or dangerous properties. Such chemicals must be handled carefully in a draft chamber. You must be familiar with the properties of chemicals you are going to use prior to experiments. Chemicals may cause health problems and accidents that involve not only the person actually using them, but others as well. In order to prevent accidents involving chemicals, make sure that you always handle chemicals properly. When handling chemicals, follow the precautions shown below.
1) A beginner must conduct experiments using utmost care, under the guidance of an expert. Experienced persons must perform all experiments carefully, even if they are already very familiar with the procedures.

2) Avoid conducting experiments alone.

3) Never leave the location of an experiment still in progress.

4) Learn adequately about the experiment you are going to perform beforehand. Then, check reagents, instruments and your protective gear before starting the experiment.

a) Understand all the properties of dangerous chemicals such as combustible/flammable substances, explosive substances, noxious substances and the like by referring to the SDS (MSDS).

b) Before conducting an experiment that can cause a fire, prepare a proper fire extinguisher and learn how to use.

c) Avoid wearing clothes, sandals or the like that allow a lot of skin exposure.

d) Always wear goggles (protective glasses) and laboratory coats during experiments. Those who are wearing contact lenses must wear goggles instead of protective glasses when conducting an experiment.

e) If necessary, prepare and wear gloves, a face shield, a gas mask and the like.

f) Check that experimental equipment is set up in an appropriate manner.

g) Glassware and handmade glass equipment often cause injuries; when handling them keep in mind that “broken glass is a potential weapon”. Do not use glass vessels that are cracked or scratched.

h) Hazardous chemicals, malodorous reagents or the like that may damage one’s health must be handled in a draft chamber. Recover highly poisonous or malodorous regents after use. When using such substances in the experimental hall (including the experimental hutch), take appropriate measures to prevent them from scattering. In the experimental hutch, take necessary measures to avoid scattering of these substances in case of leakage caused by beam radiation and the like.

i) Regents that might ignite a fire or cause a small explosion shall be handled only in a proper draft chamber made of fire- and explosion-proof materials. If necessary, use a face shield, a protection shield or the like.

j) Water-reactive and spontaneously-ignitable chemicals must be handled or stored carefully. Take necessary safety measures. Try to lower risk factors by replacing them with other substances.

k) When you must run an experiment all night or temporarily store dangerous substances or the like, take necessary safety measures.

l) Waste liquid and solid waste must be classified properly and stored in a cool, dark place while taking safety measures appropriate for the properties of waste such as placing a tray under the containers of waste liquid.

5) As a safety measure, work areas should be free of obstructions as in case an earthquake or accident should occur.

a) Do not leave reagents, instruments, equipment or the like that you do not use on a lab bench, in a draft chamber or the experimental hall (including the experimental hutch).

b) Organize reagents separately according to their category and take measures to prevent fall s.

c) Be considerate of others and keep work areas orderly when using items shared with other laboratories.

6) Take measures for prevention of environmental pollution.

a) Chemicals that might be detrimental to our health or the ecosystem (those stipulated in the PRTR Law, organic solvents/specified chemicals covered by the Industrial Safety and Health Law and the like) must be handled in a draft chamber. When using such substances in a small amount temporarily in the experimental hall and the like, ensure that the place is adequately ventilated. In the experimental hutch, take proper containment measures to prevent chemicals from scattering around in case of leakage caused by beam radiation and the like.

b) Prior to using a draft chamber, briefly check that it is properly functioning and that it does not have any broken components.

c) Collect waste solutions in a dedicated container and avoid releasing into a sink water/liquid used for primary or secondary washing.

d) Only use rotary evaporators with a diaphragm pump or water circulating cooling equipment; do not use a water aspirator. If a water aspirator is used, volatile substances might be mixed into the waste water.


After using chemicals

 When finished with chemicals, follow the measures shown below.
1) Clean up thoroughly after every experiment. Turn off gas outlets, faucets and electrical power after use. Return reagents and equipment to their proper storage locations. Leaving reagents and other items out may cause an accident.

2) If you have vacuum or gas piping in your laboratory, be sure to shut off the main valves after each use.

3)Bring back reagents you brought in, or waste and the like that were produced in your experiments.

 In case of accident

1) In case of minor abnormalities
 When an incident occurs that can be handled by personnel working at the site, follow the measures shown below:
- Judge the situation and follow the necessary measures to prevent the effects from spreading. But take such action only when your safety is ensured.
- Do not handle the incident alone. Always call someone for help.
- Contact the Beamline Toban (PHS: 3899)

2) In case of emergency
When discovering injury to the human body, significant pollution or damage to experimental facilities by chemicals and the like, or when noticing a situation potentially leading to such incidents, follow the measures shown below immediately.
- When the damage may spread, evacuate first. Before evacuating, turn off the electricity and shut off the main gas valves when possible.
- Contact the Beamline Toban (PHS: 3899)
- If you need to call an ambulance or a fire engine, inform the Guard Station (emergency call: 119 or 0791-58-0828) and they will guide the emergency vehicles. The Guard Station will alert the personnel and the authorities concerned inside and outside the campus.

3) First aid
When a chemical goes into your eyes or comes into contact with your skin, flush the affected area with running water for more than 15 minutes. If you inhale the vapor of a reagent, go outside immediately and breathe fresh air. You can see a nurse at the Occupational Health Center (ext: 3299, 999) near Large Door D3 of the Storage Ring Facility between 9:00 and 17:30 on week days. When you need to administer first aid, take a first aid kit from near the large door of the Storage Ring Facility or in area at bottom of stairs in the SACLA Experimental Building. If you need to call an ambulance, tell the Guard Station (emergency calls: 119 or 0791-58-0828) to do so. Also inform the Guard Station of the name of the room/building where the injured person is located and describe the injury, which will be reported to the ambulance on arrival.


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Last modified 2022-04-06 17:52